Mesothelioma and Virus Simian 40 (SV40)

Malignant mesothelioma has been linked to asbestos exposure. The end of this century thousands of cases of the disease found in individuals who work regularly with toxic minerals in a variety of different jobs. But nevertheless report that was released about 30 years ago by McDonald and McDonald determined that about 25-33 percent of all cases of mesothelioma cancer diagnosis does not have a definite relationship with asbestos exposure. A person who has been diagnosed with mesothelioma cancer never any contact with asbestos or asbestos-containing material.

Virus Simian 40 (SV40)

For years researchers have found some other potential causes for the cause of the growth of mesothelioma. One of mesothelioma patients may be exposed to Simian Virus 40 (SV40).

what it SV40?

SV40 is a virus that was first discovered in 1960. The virus is found in the kidney cells of rhesus monkeys. It causes kidney disease and certain cancers in the monkey population. The virus also attacks the specific tumor suppressor gene and cell death.Simian Virus 40 to the attention of the American public when it is certain that the kidney cells of rhesus monkeys the same one used in the manufacture of polio vaccines are administered to humans. This vaccine has been used from 1958 until 1963 and was given to nearly 100 million Americans. There is a sizeable number of vaccines contaminated with Simian Virus 40 and given to humans during that time period. Although exact figures are not recorded how many doses of virus contamination is given, but an estimated 10 to 30 million doses.

SV40 and Mesothelioma

Since the discovery of Simian virus 40 in millions of doses of polio vaccine, researchers have been exploring the relationship between the virus and the development of cancer in humans. Several studies have found that SV40 is present in many people diagnosed with mesothelioma disease.

A study led by Dr. Michele Carbone mesothelioma is one of the leading specialists in the US, established that more than half (about 54%) of all cases of malignant mesothelioma cancer have been infected with SV40 (Carbone, M. "Simian virus 40 and human tumors: It is time to study mechanisms. "). But they did not find the SV40 contamination in other types of lung cancer. This reinforces the finding that there is a link between SV40 and asbestos cancer, but there is no full proof that only the SV40 might be causing mesothelioma. The doctor gave the hypothesis that exposure to asbestos or immunosuppression may also be involved in this case.

A similar study conducted in 2008 at the Cancer Research Center of Hawaii and the Department of Pathology, University of Hawaii, concluded that about 60 percent of intracardiac injected hamsters with Simian Virus 40 died from mesothelioma. However a significant role SV40 against malignant mesothelioma in humans remains debatable (Rivera et al, "The Relationship between Simian Virus 40 and Mesothelioma"). Conclusion brevity authors report: "There is sufficient evidence on the relationship between simian virus 40 alone or jointly asbestos as a trigger for malignant mesothelioma. However, it is still not enough to speculate about the contribution of simian virus 40 with the overall incidence of pleural mesothelioma (mesothelioma cavity chest)."

Additional study noted that the combination of the presence of SV40 and asbestos exposure occur very frequently in improving development opportunities mesothelioma. In a 2005 report by a number of doctors and scientists Italy (Cristaudo et al, "SV40 enhances the Risk of Malignant Mesothelioma Among People Exposed to Asbestos: A Molecular Epidemiologic Case-Control Study"), the authors hypothesize that the SV40 contributes to cancer development only as an additional factor and not a direct cause.

More importantly, the study determined that "the detection of SV40 between groups of individuals exposed to asbestos could represent a useful marker for identifying those at high risk for MM (Malignant Mesothelioma - malignant mesothelioma). Subgroup of high-risk individuals can be monitored for early detection and the possibility of curative surgical excision ".

Some doctors are constantly looking for better ways to diagnose mesothelioma at an earlier stage, karenan identify high-risk individuals such as this equates to save many lives.

Source:
http://scienceblogs.com/aetiology/2010/04/malignant_mesothelioma_and_sim.php;

http://cancerres.aacrjournals.org/content/65/8/3049.full;

http://www.ncbi.nlm.nih.gov/pubmed/18520265

Mesothelioma and Virus Simian 40 (SV40)